Stem Cells Damaged by Alcohol can Cause Osteonecrosis
In Superior Healthcare Group, we always advise our stem cell patients to not drink more than one glass of wine prior to their stem cell procedure. That advice was based on data coming from studies that showed that alcoholics are prone to have bone stem cells damaged by alcohol can cause osteonecrosis. However, it turns out that alcohol might be more harmful to stem cells than what we initially thought.
Let’s discuss some of the new research that has recently been conducted.
Alcohol Consumption’s Effect on Damaging Stem Cells
However, to best explain how the stem cells damaged by alcohol happens, there needs to be a closer examination of what is occurring.
The chemical acetaldehyde (which the IARC labels carcinogen) is the catalyst. It is created organically when the body breaks down or metabolizes the alcohol inside the liver.
This process is also what causes those nasty hangovers you feel the morning after you drink too much alcohol.
So how exactly are stem cells damaged by alcohol, to begin with?
In the relationship between stem cells and alcohol, acetaldehyde is the major culprit, since it breaks the DNA of the cells.
Stem Cells and Alcohol: DNA Broken By Acetaldehyde
Researchers in this new study analyzed chromosome and also studied the effect that mice DNA had that were provided with alcohol.
This study confirmed what had been known already, which was that the acetaldehyde that is produced damages stem cell DNA.
The way it does this is through causing breaks in the DNA’s double strands. A molecule of DNA has a spiral-ladder-like shape, and the two sides of this ladder are what make up the two strands.
However, the finding that was the most interesting was how the body tries to repair its acetaldehyde-damaged cells.
To save cells from dying quickly, usually, the body repairs the cell. But a poor repair job may be performed, and the chromosomes might be rearranged to create a genomic instability along with something referred to as deletion mutations.
Oncogenetic cells (cells that contain cancer-causing genes) are created by these mutations. So if a shoddy repair job causes the process to go south, there is potentially a cancer cell now. If it is activated it can proliferate and result in cancer.
The new study reports that it is the acetaldehyde damage to the stem cell’s DNA that stimulates this.
A note on cells that have cancer-causing chromosomes. Our bodies get those cells on a daily basis, but a healthy and normal immune system will attack and kill them.
However, whenever the immune system is not diligent and strong enough to get rid of those cells, cancer can occur.
Despite the relationship between stem cells and alcohol, there are other things that harm our stem cells as well.
How Stem Cells Damaged by Alcohol
Alcohol might not be a problem for you, but that doesn’t necessarily mean that your stem cells are in great shape. The following are some of the other ways that your stem cells might be harmed:
It has been shown that consuming too many carbs and sugar can affect stem cells by stifling their potential for regenerating.
Cancer cells also thrive on sugar. When you have poorly repaired or damaged DNA, like from alcohol that was mentioned above, you may be especially vulnerable to sugar. Stem cell function might be disrupted by excessive calorie consumption by causing insulin resistance, particularly if many of the calories are carbs and sugar.
Lack of exercise might cause you to miss the chance to increase your muscle stem cells, and in turn, muscle mass. Although that might not harm your stem cells directly, it won’t benefit them either.
Being overweight can negatively affect your stem cells’ health. Not getting a sufficient amount of sleep might disrupt the circadian rhythm of your stem cells, which can potentially damage the cells and cause them to age faster.
Nonsteroidal anti-inflammatory drugs (NSAIDs) might cause defective cartilage to be produced by stem cells.
In summary, stem cells are impacted by alcohol.
It isn’t a human study, so we don’t really know if your stem cell procedure will be impacted by having one glass of wine.
Until we know for sure, we recommend that you completely stay off alcohol a couple of weeks before and then after your procedure.
Schedule a free consultation and let us show you how we can help you reach your health and wellness goals. You owe it to yourself to find relief from your pain.